When used in pulmonary arterial hypertension patients, however, the oral bioavailability of sildenafil after a dosing regimen of 80 mg three times a day, was on average 43% greater than compared to the lower doses .In vitro studies have shown that sildenafil is selective for phosphodiesterase-5 (PDE5) . Its effect is more potent on PDE5 than on oth

Administration of CIALIS to clients who will be applying any sort of organic and natural nitrate, is contraindicated.In clinical pharmacology scientific studies, CIALIS was shown to potentiate the hypotensive effect of nitrates. In a very individual who may have taken CIALIS, where by nitrate administration is considered medically needed in a lifes